Myofibroblast

Myofibroblasts are a cell type that was first described in wound healing. They also occur as pericytes in the capillary walls and in the so-called tunica albuginea of the testis. They represent an intermediate form between smooth muscle cell and fibroblast and contain contractile actin and myosin filaments, and high endogenous production of collagen. Myofibroblasts contract with the help of a smooth muscle actin - myosin complex, which is rich in alpha- smooth muscle actin.

Myofibroblasts arise mostly from fibroblasts were stimulated by activated macrophages ( in wounds) for cell division. This resulting myofibroblasts migrate into the wound area with the macrophages. By replacing macrophage white blood cells, they stimulate the immigration of other myofibroblasts and fibroblasts and their proliferation. These in their turn increase the production of collagen type III ( reticular fibers), the precursor of the connective tissue network of type I collagen and contribute to scarring.

  • Cell type
  • Testicle
589306
de