Myolie Wu studied at the Hong Kong University of Science and Technology Biochemistry and later at Methodist College Belfast OLR. In 1999, she finished in the Miss Hong Kong second place and was acting in some television series. Her talent was discovered only after the series Golden Faith (流 金 岁月).
On May 2008 she signed a contract with a record company. The end of 2008 it got two popular prices than newcomers.
- 2003: Virtues of Harmony II (皆大欢喜)
- 嫁 衣裳: Lost In The Chamber Of Love (西厢 奇缘) with Ron Ng (吴 卓 羲)
- 同 捞 同 煲: Scavengers ' Paradise (同 捞 同 煲) with Roger Kwok (郭晋安), Kenneth Ma (马国明) and Cherie Kong (江 芷妮)
- 家 规: Wars of In -laws (我 的 野蛮 奶奶) with Elizabeth " Liza " Wang (汪明荃) and Bosco Wong (黄宗泽)
- 幸而: War and Destiny (乱世佳人)
- 丑 得 漂亮: To Grow With Love (肥田 囍 事) with Andy Hui (许志安)
- 猪 小姐: To Grow With Love (肥田 囍 事)
- 感激 遇到 你: Wars of In-Laws II (野蛮 奶奶 大战 戈 师奶) with Bosco Wong (黄宗泽)
- 朱古力 与 云 呢 拿: Sugar Sugar Rune (魔女 的 考验) with Bernice Liu (廖碧 儿)
- 最 难过 今天: Wars of In-Laws II (野蛮 奶奶 大战 戈 师奶) with Vincent Wong (王浩信)
- 当 狗 爱上 猫: When A Dog Loves A Cat (当 狗 爱上 猫) with Gallen Lo Ka -leung (罗嘉良)