Nedocromil

IUPAC: 9 -ethyl-6 ,9 -dihydro -4 ,6- dioxo- 10 -propyl- 4H- - pyrano (3,2 -g ) quinoline- 2 ,8 -dicarboxylic acid

• C19H17NO7 ( nedocromil )
• C19H15NNa2O7 ( nedocromil disodium salt)

• 69049-73-6 ( nedocromil )
• 69049-74-7 ( nedocromil disodium salt)

R01AC07, R03BC03, S01GX04

Antiasthmatic

• 371.34 g · mol -1 ( nedocromil )
• 415.30 g · mol -1 ( nedocromil disodium salt)

298-300 ° C ( decomposition)

Soluble in water ( nedocromil disodium salt)

Template: Infobox chemical / molecular formula search available

Nedocromil is a drug which is used for the prophylaxis and treatment of allergic symptoms and is sold in German-speaking from Sanofi - Aventis.

Pharmacology

Field of application and mode of action

Nedocromil is used in addition to cromolyn sodium for the treatment of seasonal allergic conjunctivitis ( allergic conjunctivitis ). They both belong to the group of medicines Cromones.

Both substances can be administered prophylactically as an alternative to inhaled glucocorticoids in slight allergic and non-allergic asthma, as well as. However, for the treatment of acute asthma symptoms nedocromil is not suitable.

Nedocromil has a stabilizing effect on histamine -storing or producing mast cells by Degranulationshemmung, that is, by inhibiting the release of mediators. This effect occurs in its entirety but only about a month after starting treatment.

Trade names

The mono-preparations containing the disodium salt (CAS No. 69049-74-7 ): Irtan (D), Tilade (A) and Tilavist (A, CH).