Nefazodone

1 - {3 - [4 - (3- chlorophenyl) piperazin-1 -yl] propyl} -3 -ethyl -4 -(2- phenoxyethyl) - 4,5 -dihydro-1, 2,4 - triazol-5 - on

  • 83366-66-9 ( nefazodone )
  • 82752-99-6 ( nefazodone · hydrochloride)

N06AX06

Antidepressants

Serotonin -norepinephrine reuptake inhibitors

Fixed

  • 83-84 ° C ( nefazodone )
  • 175-187 ° C ( · nefazodone hydrochloride)
  • Insoluble in water ( nefazodone · hydrochloride)
  • Soluble in DMF [10 g · l -1 ( · nefazodone hydrochloride) ]

Hydrochloride

Template: Infobox chemical / molecular formula search available

Nefazodone is the class of antidepressants dualserotonergen ( DSA) belonging antidepressant. It is a phenyl piperazine derivative that is structurally and partly also in its mode of action to the already longer known antidepressant trazodone is similar.

Operation

The antidepressant effect of nefazodone via two mechanisms. Blocking a part of the serotonin 5- HT2A receptor, and on the other hand, to a lesser extent, also the presynaptic reuptake of serotonin.

Nefazodone has no significant affinity to α - or β -adrenoceptors as well as histamine, dopamine, and acetylcholine receptors.

History

In Germany it was sold from 1997 by Bristol -Myers Squibb under the name Nefadar, in the U.S. it was sold under the name Serzone.

Due to some cases of severe liver failure, the drug was taken off the market in 2003.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Serotonin–norepinephrine reuptake inhibitor 5-HT receptor Histamine receptor Bristol-Myers Squibb
596637
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