Nitrendipine
IUPAC: ( R, S) -ethyl- 5-( methoxycarbonyl) - 2,6-dimethyl- 4-( 3-nitrophenyl) - 1,4- dihydropyridine -3-carboxylate
C08CA08
Antihypertensives
Calcium antagonist
158-160 ° C
Water: 77.2 mg · l-1 at 25 ° C
Attention
2540 mg · kg -1 ( LD50, mouse, oral)
Template: Infobox chemical / molecular formula search available
Nitrendipine is a drug from the group of calcium antagonists of the 1,4- dihydropyridine type. It lowers an extension of the smooth muscle of the vessels the blood pressure considerably. Therapeutically, it is used for treatment of arterial hypertension.
Mechanism of Action
Nitrendipine blocks the calcium influx into the cardiac muscle, smooth muscle, and in the excitement of education and conduction system of the heart. This leads to the heart to a reduced contractility ( negative inotropic ) and a reduced O2 consumption. On smooth muscle, it causes dilation of small arteries ( arterioles ) and thus a afterload. Nitrendipine is a dihydropyridine. In therapeutic doses is the effect of nitrendipine and other dihydropyridine calcium antagonists hardly at heart, but almost exclusively on vessels.
Indications
Nitrendipine is approved in Germany for the treatment of essential arterial hypertension and acute as Bayotensin ® for the treatment of hypertensive emergency.
Side effects
Frequently it comes to the appearance of lower leg edema, headache and flushing, as well as occasional dizziness, fatigue, and hypoesthesia.
Rare side effects include tachycardia, palpitation, nausea, bloating, diarrhea, and increased urinary frequency.
Contraindications
In cardiogenic shock, unstable angina pectoris, myocardial infarction (within the first 4 wk. ) And children ( lack of experience ) is contraindicated the administration of nitrendipine.
Trade names
Bayotensin (D), Baypress (A, CH), Jutapress (D ), numerous generics (D)
Baroprine (A), Cenipres (A), Enea (D)