Nitroxoline

J01XX07

Antibiotic

From 179.5 to 181.5 ° C

Risk

104 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Nitroxoline is a 1967 introduced in the market antibiotic and antifungal drug from the group of 8- hydroxyquinoline derivatives, which is used to treat acute and chronic infectious diseases of the urinary tract, caused by Nitroxoline - sensitive bacteria and yeasts used. These include urinary tract infections, for example, cystitis ( bladder infection ) and urethritis ( inflammation of the urethra ). The drug is also used to recurrence prophylaxis. Nitroxoline is in Germany under the trade name Cysto - saar ® MIP Pharma GmbH and as a generic midi Nitroxoline / forte of roses Pharma GmbH in the trade.

As an undesired side effects occur relatively frequently upset stomach, nausea and vomiting. The usual treatment period is between seven and ten days. In contrast to other antibiotics, the available data on safety and efficacy is comparatively small, also because of the insert is substantially in Germany is limited and the drug is hardly used internationally.

Synthesis

For the synthesis of 8-hydroxyquinoline Nitroxoline can be converted to 8- hydroxy-5- nitrosoquinoline with sodium nitrite and hydrochloric acid. This can be oxidized with nitric acid to Nitroxoline again.