• DIC
  • Diisopropylcarbodiimide

Colorless liquid


0.815 g · cm -3

145-148 ° C

1.433 (20 ° C)


Template: Infobox chemical / molecular formula search available

N, N'- diisopropylcarbodiimide (DIC ) is a carbodiimide, and finds application as a coupling reagent in peptide synthesis. As a liquid, it is easier to handle in comparison with the likewise used for this purpose dicyclohexylcarbodiimide.

Diisopropylcarbodiimide is used in peptide coupling as activating reagent by reacting it with the carboxylic acid function is a so-called active ester in the course of the reaction, which then reacts with an amino group to the amide ( peptide bond ). Furthermore, it binds the water during the reaction formally formed irreversibly, where the products can diisopropylurea arises. DIC is used both at a peptide synthesis in solution and at a peptide synthesis on solid phase.