Osaterone

( )- 6-chloro- 17- hydroxy-2- oxapregna -4 ,6- diene-3 ,20-dione

QG04CX90

Antiandrogens

Inhibition of testosterone uptake in the prostate cells

Insoluble in water, freely soluble in chloroform and tetrahydrofuran

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Osaterone is a synthetic antiandrogen that is chemically related to chlormadinone. It is used in animal medicine as an ester of acetic acid ( Osaterone acetate, trade name Ypozane ) for the treatment of benign prostatic hyperplasia use. It inhibits testosterone uptake in the prostate cells, while the serum level of testosterone is virtually unaffected.

The drug is well absorbed following oral administration. The plasma protein binding is 87-92 % in the dog. Osaterone is metabolized in the liver and excreted in bile, feces and urine. The elimination half -life is about 80 hours.

Osaterone is well tolerated. As side effects increased appetite and personality changes may occur. Since the active ingredient also, albeit low affinity for glucocorticoid receptors has, it may be a slight decrease in cortisol concentration in serum, but not clinically manifested. The administration of the drug should therefore be carried out at Adrenal Insufficiency only under strict indications and can affect the results of an ACTH stimulation test.