Otto Folin

Otto Knut Olof Folin ( born April 4, 1867 in Åseda, † October 25, 1934 ) was a Swedish- American pioneer of the clinical biochemistry.

Life

Born the youngest of twelve sons and one daughter of a family with small land holdings in Småland in Sweden, moved over the age of 15 shortly after his confirmation in the U.S., because in Minnesota, two brothers and an aunt were already living. In Sweden, he had learned some German. His English skills acquired and he deepened not only at a school in Stillwater, but also during various student jobs around the St. Croix Boom Site in passing.

He attended the University of Minnesota from 1888 to 1892, where Julius Stieglitz was one of the supervisors. 1890 Folin U.S. citizens. Then he deepened his knowledge of physiological chemistry at the University of Uppsala, resulting in his first scientific publication in " Hoppe- Seyler 's Journal of Physiological Chemistry " resulted. From the subsequent work in Ernst Leopold Salkowski laboratory, a working for the determination of uric acid showed. Then he worked in Albrecht Kossels laboratory at the University of Marburg.

Back in the U.S., he received his Ph.D. at the University of Chicago in 1898. After he became assistant professor at West Virginia University and therefore to Morgantown (West Virginia) had moved, he married on September 11, 1899 Laura Churchill Grant, 1896 her MA had made in economics. The daughter Teresa from this marriage made ​​later graduated from the School of Medicine of the Johns Hopkins University, the son Grant was, like his father, Otto amateur golfer and businessman was in Detroit, while the other daughter Joanna died in 1912. 1890 Folin went to the McLean Hospital in Belmont, Massachusetts, where he could set up a new laboratory for physiological chemistry. There he developed analytical methods for urine and blood. 1903 remote to him in the Massachusetts General Hospital, a benign tumor in the facial area, in which a nerve was severed, resulting in a permanent change in his appearance. 1905 brought him a wide publication of scientific recognition, in which he stated that the amount of creatinine in the urine does not depend on the amount of the ingested protein - in contrast to urea, for which there is such a connection.

In 1907 he was appointed assistant professor at the Medical School of Harvard University and two years later there as professor of biochemistry. In his laboratory, he took on more staff and students, including George Richards Minot. Further work led to the development of the Folin -Ciocalteu reagent, which also enabled the protein determination according to Lowry. In 1909 he became president of the American Society of Biological Chemists, which was later renamed American Society for Biochemistry and Molecular Biology. In 1916 he was elected member of the National Academy of Sciences. The Washington University in St. Louis in 1915 awarded him an honorary doctorate from the University of Chicago followed in 1916 and the University of Lund in 1918. 's Imperial Leopoldinisch - Carolinian German Academy of Natural Scientists, he became a member in 1932.

His last publication appeared in 1934 in the Journal of Biological Chemistry, the longtime co-editor he was. He died of a myocardial infarction.

Works

  • Otto Folin: Laboratory manual of biological chemistry, 1919
  • Otto Folin: Preservatives and Other Chemicals in Foods, 1923

Swell

  • Phillip Anderson Shaffer, National Academy of Sciences: Otto Folin, 1952
  • Robert D. Simoni, Robert L. Hill and Martha Vaughan Analytical Biochemistry: the Work of Otto Knuf Olof Folin on Blood Analysis. In: The Journal of Biological Chemistry, 277, e9.
  • Management of Wilderness and Environmental Emergencies In: Annals of Internal Medicine 1989, 111 (3): 265 doi: 10.7326/0003-4819-111-3-265_1
  • Frank H. Wians, Jr: Luminaries in Laboratory Medicine: Otto Folin. In: LabMedicine (2009), 40, 54-55. doi: 10.1309/LMTOH5WLUQX26AIC
  • Otto Folin 's Decade in Minnesota, 1882-1892: A Brief Review. (PDF, 1.5 MB): CLIN. CHEM. 28/10, 2173-2177 (1982).
  • Biochemist
  • University teachers (Harvard University)
  • University teachers (West Virginia University)
  • Member of the National Academy of Sciences of the United States
  • Member of the Leopoldina ( 20th century)
  • Honorary Doctor of the University of Chicago
  • Honorary Doctor of the University of Lund
  • Swede
  • Americans
  • Born in 1867
  • Died in 1934
  • Man
Stillwater (Minnesota) Belmont (Massachusetts) Folin–Ciocalteu reagent Digital Object Identifier Integrated Authority File
627045
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