Oxazolidine

• Oxazolane
• 1,3 - oxazolidine (IUPAC)

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Oxazolidine, formerly oxazolane, is a chemical compound. The heterocyclic compound is a hydrogenation product of the oxazole and base the group of oxazolidines.

Occurrence and representation

In nature, many of the oxazolidine derivatives, mostly as oxazolidinones before; the parent compound oxazolidine itself has not been found.

By reduction of oxazoles with alcohols and the sodium oxazolidines can be obtained. They may also be prepared by reacting β -amino alcohols with aldehydes. As formed in the reaction of formaldehyde with 2-amino -2-methylpropanol used as an industrial biocide, the 4,4-dimethyl- 1 ,3 -oxazolidine.

Use

Previously oxazolidine and its derivatives paramethadione and trimethadione were used as antiepileptic drugs; due to relatively high toxicity and required high doses, the use has been discontinued now. Oxazolidines act on the synapses by extending their refractory period.

Currently oxazolidines be used as microbicides in lubricants. Here, they act by split off formaldehyde upon heating, which kills bacteria and fungi.

Oxazolidines are also used as so-called latent curing in air- moisture-curing polyurethane systems. Amino alcohols are released by hydrolysis, will react with isocyanates under polyaddition to form urethane and urea groups.