PAEP

Glycodelin is a protein that is produced in the endometrium of primates. It has modulating function on the immune system. Because of its affiliation to the family of lipocalins, it probably has the function of a transport protein. It is the most abundant protein that is secreted in the endometrium during the mid-to late luteal phase and the first semester of pregnancy, about 6-8 days after progesterone. There are three isoforms of the protein which arise by alternative splicing of the mRNA. Depending in which tissue glycodelin synthesized, it is present in a different glycosylation. The Glycodelin the semen may have regulatory function in contraception. The beta- lactoglobulin in the milk of mammals is closely related to glycodelin.

There is a relationship between the Glycodelinspiegel and the perception of pain during menstruation.

Glycodelin has a molecular mass of 28 kDa. It is a homodimer with a molecular mass of 50-60 kDa. It consists of 180 amino acids. Is encoded on chromosome 9 Glycodelin glycodelin A from amniotic fluid carries as glycosylation or LacNAc lacdiNAc which have immunosuppressive effects by blocking adhesive and activating events that are mediated by CD22, the human B -cell receptor, and Lewis X, the e-selectin - mediated adhesion blocked. Glycodelin S from seminal plasma.

History

In the 70s and 80s, a protein isolated from different tissues, which got different names depending on the tissue from which it was isolated. After determination of the oligosaccharide structure of these proteins Glycodelin were called.

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