Palonosetron

2 - [( S)- quinuclidin-3 -yl] - ( 3aR ) -2,3,3 a, 4,5,6 - hexahydro -1H -benzo [ de ] isoquinolin -1-one

  • C19H24N2O ( palonosetron )
  • C19H24N2O · HCl ( palonosetron hydrochloride · )

A04AA05

Antiemetics

Selective blockade of central 5 -HT3 receptors

  • 296.41 g · mol -1 ( palonosetron )
  • 332.87 g.mol -1 ( · palonosetron hydrochloride)

87-88 ° C ( palonosetron )

Readily soluble in water, slightly soluble in ethanol and 2- propanol ( palonosetron )

Template: Infobox chemical / molecular formula search available

Palonosetron is a in Germany in 2005, and in Austria and Switzerland under the trade name Aloxi ® ( Manufacturer in Germany: Riemser drugs) for the prevention of nausea and vomiting in chemotherapy of cancers of approved drug and therefore belongs to the group of anti-emetics. Ondansetron as well as the already longer available, it belongs to the group of the 5- HT3 receptor antagonists, with a plasma half -life of about 40 hours, it has a much longer duration of action as ondansetron on. There are 250 micrograms palonosetron given approximately 30 minutes before chemotherapy intravenously, with repeated dosing is not recommended within seven days.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Isopropyl alcohol Active ingredient 5-HT receptor
51295
de