Pancreatic polypeptide

• OMIM: 167780
• UniProt: P01298

The pancreatic hormone ( also briefly PP for pancreatic polypeptide ) is a peptide hormone consisting of 36 amino acids from the PP- or F- cells of the islets of Langerhans of the pancreas ( pancreas), the concentration increases to the protein-rich food in the blood.

It is a hormone of the gastro -intestinal canal, which inhibits the enzyme and hydrogen production of the pancreas, the motility of the intestine and the bile flow.

Primary structure

H2N-Ala–Pro–Leu–Glu–Pro–Gln–Tyr–Pro–Gly–Asp–Asp–Ala–Thr–Pro–Glu–Gln–Met– Ala–Gln–Tyr–Ala–Ala–Gln–Leu–Arg–Arg–Tyr–Ile–Asn–Met–Leu–Thr–Arg–Pro–Arg–Tyr-COOH.

Function

Since 1970, the relationship between PP ( pancreatic polypeptide ) and appetite regulation is explored. Thus, in obese mice, the lack of PP was observed, in which the injection of PP resulted in a decreased appetite and weight loss. Also in other studies, it was found that injection of PP reduces appetite for about 24 hours. In addition, stimulates sympathetic activity and oxygen consumption on PP, so it will consume more energy. In mouse studies, a positive effect of PP could be found on metabolic parameters such as cholesterol. Of interest was the fact that the central administration of PP increased food intake in animal models, central PP thus has the opposite effect. Also, studies in humans show the appetite inhibition by PP and the associated weight loss, both in overweight and normal weight. However, it could not be shown that gastric emptying and intestinal motility of PP is affected.