PDGFA

  • OMIM: 173430
  • UniProt: P04085
  • MGI: 97527

Platelet- derived growth factor A ( PDGF -A) is one of four growth factors of the PDGF family. The protein is released both in violation of the platelets and stimulates new cell growth in the surrounding tissue, and it plays an important role in the development of the embryo; Mice that were born without this protein, underdeveloped testes, no Leydig cells and altered sperm have ( spermatogenic arrest ).

Biosynthesis

The gene coding for the human PDGF -A gene is located on chromosome 7, and consists of six exons spread over 18,900 base pairs. The 1431 -base-long transcript is translated into a 211 amino acid long protein which, after removal of the N -terminal signal peptide ( 20 amino acids) results in the propeptide. After the elimination of a further 66 amino acids, the main isoform of PDGF- A in the other isoform of the C-terminal 15 amino acids are missing is produced. The two isoforms thus have a length of 125 and 110 amino acids.

Biological Function

The biological function of stimulating wound and during embryogenesis are mediated through binding of the A A- A B, or to one of the dimers, PDGF - receptors that act as tyrosine kinases.

  • Growth factor
  • Embryology
Protein isoform Human Genome Organisation Mouse Genome Informatics Euteleostomi Entrez Ensembl National Center for Biotechnology Information Platelet Derived Growth Factor
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