Pentylenetetrazol

  • Leptazol
  • Pentylenetetrazol
  • Metrazol
  • 6,7,8,9 -tetrahydro- 5H- tetrazoloazepin (IUPAC)

R07AB03

Fixed

Risk

Template: Infobox chemical / molecular formula search available

Pentylenetetrazol, INN, (trade name Cardiazol ®) is a bicyclic tetrazole derivative. It is used as a circulatory stimulant and stimulates the brain located in the centers of respiration and heart activity here. In high doses it triggers spasms, which is why it was formerly used in the shock therapy.

Representation

6,7,8,9 -tetrahydro- 5H- tetrazolo - azepine is produced by the action of 2 molecules of hydrazoic acid to a molecule of cyclohexanone.

Importance

Cardiazol was discovered by the German chemist Karl -Friedrich Schmidt. The Hungarian- American neurologist and psychiatrist Ladislas J. Meduna used the first time Cardiazol 1934. Application triggered mainly from cramps, and so Cardiazol was mainly used in shock therapy. Admission to the application was withdrawn in 1982 by the Food and Drug Administration. Recent studies show a potential efficacy in a mouse model of Down syndrome.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC)
163457
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