Perisinusoidal space

The space of Disse is about 10-15 microns wide anatomical gap between the advanced Leberkapillaren ( liver sinusoids ), and the liver cells (hepatocytes ). It is named after the German anatomist Joseph Disse ( 1852-1912 ).

Because the liver sinusoids have a discontinuous endothelium without basement membrane, the blood plasma can pass directly into the space of Disse. In the space of Disse extend the microvilli of hepatocytes, are absorbed through the proteins, low molecular weight compounds and liquid in the liver cell. The liquid of the Disse space oozes from over lymphatics in the portal fields. In the space of Disse to find a special type of stellate cells, which are known as Ito cells.

Since the oncotic pressure in the liver sinusoids and the Disse space has hardly a gradient, the lymph from the pressure in the sinusoids depends. Increases the sinusoidal pressure by a mmHg, the lymph doubled. If the transport capacity of the lymphatic vessels is exceeded, such as portal hypertension, ascites developed by crossing the lymph into the abdominal cavity.