Phosphatidylinositol 3,4-bisphosphate

The phosphatidylinositol -4 ,5- bisphosphate ( PIP2 Abbr ) are a group of phospholipids exclusively in the cell side facing the interior of the cell membrane occur almost.

They play an important role in the transduction of extracellular signals into the cell (eg, the signal transduction pathway of insulin ) and check endocytosis. By activating certain receptors that are located in the cell membrane results in activation of the enzyme phospholipase C. The phospholipase C cleaves PIP2 hydrolysis in diacylglycerols (DAG ) and inositol -1 ,4,5- trisphosphate (IP3 ). Both products of this cleavage can contribute as so-called second messengers to relay the signal into the cell.

Phosphoinositide -3- kinases (PI3K ), however, convert to PIP2 phosphatidylinositol -3 ,4,5 -triphosphate ( PIP3 ). The reverse reaction of PIP2 to PIP3 effected by the phosphatase PTEN.