Phosphodiesterase-4 inhibitor

Phosphodiesterase - 4 inhibitor (also phosphodiesterase IV inhibitors, PDE -4 ) inhibitors are substances that inhibit the enzyme phosphodiesterase IV. The phosphodiesterase IV degrades the second messenger cAMP. Therefore, PDE - 4 inhibitors increase the concentration of intracellular cAMP. The enzyme is, inter alia, present in the lungs.

The prototype of the phosphodiesterase - 4 inhibitor rolipram is. PDE - 4 inhibitors are anti-inflammatory and performed at several investigated in the fields of application of COPD, bronchial asthma, depression and multiple sclerosis. So far, however, only one drug has been approved as a drug: Roflumilast ( Daxas ®). Developing cipamfylline was adjusted.