Phosphoprotein

Phosphoproteins are proteins that have been post-translationally modified by the attachment of a phosphate group (phosphorylation ). The amino acids of the protein are affected most serine, threonine or tyrosine ( eukaryotes ), or aspartic acid, or histidine ( prokaryotes ). The phosphorylation is catalyzed by protein kinases and phosphatases from.

The UniProt database contained in 2010 more than 90,000 entries to phosphoproteins. The PhosphoSitePlus Database registered in 2013 about 206,000 phosphorylation sites in nearly 20,000 phosphoproteins. About a third of the proteome of mammals are phosphoproteins.