Piracetam

IUPAC: 2- oxopyrrolidin -1 -acetamide

N06BX03

Antidementia

From 151.5 to 152.5 ° C

2000 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Piracetam is a cyclic derivative ( γ -lactam ) of the γ -aminobutyric acid ( GABA) and a drug from the group of anti-dementia drugs ( nootropics ).

It stimulates the cellular metabolism of sugar and oxygen utilization in the brain and is used for the symptomatic treatment of chronic organic brain -related performance impairment ( dementia).

By Piracetam may occur as part of an overall therapeutic concept to an improvement of the symptoms memory, concentration and thought disorder, drive, and lack of motivation and fatigue in people with dementia. A causal therapy of dementia is currently not possible. The sustained efficacy Piracetams in dementia is controversial.

Piracetam is sometimes also prescribed for systemic treatment of sudden deafness to promote blood circulation.

Chemically related substances ( analogues) are, inter alia, aniracetam, and oxiracetam Pramiracetam.

Production

Two different syntheses of piracetam, starting from 2 -pyrrolidone are described in the literature.

Side effects

While taking or use of piracetam among others the following side effects may occur occasionally: Agitation, increased drive, nervousness, restlessness, irritability, aggressiveness, tremor, depression, anxiety disorders, insomnia, fatigue and drowsiness, nausea, vomiting, abdominal pain, diarrhea, weight gain.

Rather rare side effects include: Dizziness, weakness, lowering blood pressure, increased blood pressure, increased appetite (libido).

Very rare and therefore isolated and sporadic side effects may include the following: Headache, movement disorders, incoordination, confusion, delusions, allergic reactions such as anaphylactic shock, urticaria, erythema, flushing, itching, sweating.

Trade names

Cerebryl (A), Cerepar (D), nootropic (D), nootropil (A, CH), Norma Brain (D), Pirabene (A ), various generics (D)