The Paraneoplastic antigen Ma2 ( PNMA2 ) is a protein with unknown function. A participation in programmed cell death ( apoptosis) is suspected. The protein is encoded by the same PNMA2 gene is localized in humans on the short arm of chromosome 8 ( 8p21 ). The paraneoplastic antigen Ma2 belongs to PNMA family.

It is naturally produced in the brain. In addition, it is formed by certain cancer cells, most of cancer cells in testicular cancer.

Medical importance

In some neurological disorders antibodies in both the cerebrospinal fluid ( CSF) and in blood serum are detectable that the paraneoplastic antigen Ma2 are directed against the. When the disease is paraneoplastic syndromes, especially for testicular cancer: the limbic encephalitis and brain stem encephalitis. Signs of the two diseases can occur in parallel and are summarized as anti - Ma2 -associated encephalitis.

Further Reading

  • R. Voltz, SH Gultekin, among other things: A serologic marker of paraneoplastic limbic and brain - stem encephalitis in patients with testicular cancer. In: The New England journal of medicine. Volume 340, Number 23, June 1999, pp. 1788-1795, ISSN 0028-4793. doi: 10.1056/NEJM199906103402303. PMID 10,362,822th
  • M. Schüller, D. Jenne, R. Voltz: The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. In: Journal of neuroimmunology. Volume 169, Number 1-2, December 2005, pp. 172-176, ISSN 0165-5728. doi: 10.1016/j.jneuroim.2005.08.019. PMID 16,214,224th
  • T. Cui, M. Hurtig, among other things: Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors. In: PloS one. Volume 5, Number 12, 2010, p e16010, ISSN 1932-6203. doi: 10.1371/journal.pone.0016010. PMID 21,209,860th PMC 3012732 (Free full text ).