Prokinetic agent

A prokinetic agent (from the Greek for πρό and κινέω move ) is a drug that increases the peristalsis of the gastrointestinal tract. It works by promoting the Vorwärtsperistaltik and inhibits Rückwärtsperistaltik. Accordingly, the areas of application: For one, they can by inhibiting the Rückwärtsperistaltik be effectively used to control nausea and vomiting ( This group is also known as antiemetics. ). On the other hand, they can also be used against a constipation (paralytic ileus), a typical complication following surgery to the abdominal organs as well as a side effect of some medications (especially strong pain medicines such as opiates and certain psychotropic drugs).

Representatives:

• Cholinergics (e.g., carbachol )
• Dopamine receptor antagonists (e.g., metoclopramide, domperidone )
• 5-HT4 receptor agonists (e.g., cisapride )