Propyphenazone

• 4 -isopropyl-2 ,3-dimethyl -1-phenyl -3 -pyrazolin- 5-one
• 1,5-dimethyl -4-( 1-methylethyl) - 2 -phenyl-1 ,2 -dihydro -3H -pyrazol- 3-one
• Isopropyl antipyrine

N02BB04

White to slightly yellowish crystalline powder

102-106 ° C

Sparingly soluble in water, slightly soluble in dichloromethane and ethanol 96 %

860 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Propyphenazone is a pyrazolone derivative, and is used as a non-steroidal anti-inflammatory, antipyretic and analgesic. It was by Hoffmann- La Roche as Saridon ® 1933 (in combination with phenacetin, and caffeine Pyrithyldion, no longer available in D) placed on the market.

Pharmacology

Propyphenazone inhibits the production of prostaglandins, thereby reducing the pain and inflammation. It dampens the pain processing and pain sensation in the brain. The antipyretic effect is produced by an influence of the temperature control center in the brain. There is only weak anti-inflammatory and has a slight antispasmodic effect that may have a beneficial effect on headaches.

Application

• Fever
• Mild to moderate pain

Known side effects

• Allergic reaction (hypersensitivity reactions, such as skin reactions (redness, itching), shortness of breath, palpitations ( rare) )
• Gastrointestinal complaints
• Inflammatory changes in the kidney tissue (interstitial nephritis)
• Blood disorders (rare)
• Skin reaction with painful blisters ( Stevens- Johnson syndrome) (very rare or isolated cases)
• Blistering of the skin with destruction of skin layers ( Lyell 's syndrome) (very rare or isolated cases)

There is no evidence of interactions with other medicines.

Contraindications

• Hypersensitivity to pyrazole
• Severe liver disease