Pseudomonas exotoxin

Exotoxin A is known as a major, virulent lectin from the bacterium Pseudomonas aeruginosa. The molecular mass is 66.5 kDa. Exotoxin A polypeptide is comprised of three domains, each of which has ADP - ribosyltransferase activity, whereas the two other domains bind to the toxin -sensitive cells and are responsible for the penetration of the first domain in the cytoplasm through the cell membrane.

The biochemical response is identical to the response of diphtheria toxin A, that is, the elongation eEF -2 is bound to a EF2 ADP ribosyl complex and is thus no longer available for protein synthesis.

Pseudomonas aeruginosa Transcription (genetics)#Elongation
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