Quinolinic acid

Pyridine-2 ,3-dicarboxylic acid

Crystalline yellow powder, sensitive to light

Fixed

Decomposition from 185-190 ° C

• PKS1 (25 ° C) = 2.41
• PKS2 (25 ° C) = 5.05

Slightly soluble in water (10 g · l-1 at 20 ° C)

Attention

> 500 mg · kg -1 ( LD50, rat, oral)

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Quinolinic acid ( pyridine-2 ,3 -dicarboxylic acid) is a chemical compound from the group of pyridine dicarboxylic acids. It consists of a pyridine ring, the 2 - and 3- position carries carboxyl groups.

Occurrence

Quinolinic acid occurs naturally as a metabolite of tryptophan.

Production and representation

Quinolinic acid can be prepared by electrochemical oxidation of quinoline or with the aid of hydrogen peroxide.

Alternatively, it may be prepared from quinoline by oxidation with potassium permanganate ( KMnO4 ). It is formed as an intermediate in the synthesis of nicotinic acid. Quinolinic acid decomposes above 185-190 ° C by decarboxylation to nicotinic acid.