Radioactive iodine uptake test

The Radiojodtest is the examination of thyroid function by administration of a radioactive Jodisotops - usually 131Jod or 123Jod - and subsequent measurement of radioactivity over the thyroid gland.

Until the 1980s Radiojodstudien to assess the metabolic status of the thyroid gland were common. In diagnostics and uptake measurements after 4 to 24 hours are now only occasionally in conjunction with a Schilddrüsenzintigraphie with 123Jod performed to distinguish diseases with high Joduptake (eg Graves' disease ) and those with low iodine intake (eg, thyroiditis ) safe to be able to. In the routine it is sufficient to simply measuring uptake during scintigraphy with iodine or 99mTechnetium connected with high-precision determination of thyroid hormones in the blood serum.

To prepare for a radioiodine therapy for benign thyroid disease the Radiojodtest is also common to determine the time necessary for the individual patient activity. Usually be about 5 MBq of I-131 administered and the uptake in the thyroid gland of a particular probe or a gamma camera after 6, 24 and 48 hours was measured. From the measured values ​​of stored iodine content in percent and its biological half-life can be estimated. After the so-called Marinelli formula now, the required amount of iodine therapy to be calculated (see radioiodine # determine the appropriate therapy activity).

Sources and References

  • Robert F. Dons, Frank H. Wians, Jr.: Endocrine and Metabolic Disorders: Clinical Lab Testing Manual, Fourth Edition. Taylor & Francis 13 July, 2009, ISBN 978-1-4200-7936-4, p 30
  • Torsten Kuwert: nuclear medicine. Georg Thieme Verlag, 2008, ISBN 978-3-13-118504-4, p 383
  • The diagnostic method in endocrinology
  • Diagnostic procedures in nuclear medicine
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