Rebound effect

The term rebound or recoil (of English rebound -. Rebound ) called in medicine the rapid, increased recurrence of medically treated disease after discontinuation of the drug.

These effects and the phenomena are based, inter alia, that there is a decrease in the number of receptors for the treatment, the affected area occupied before the drug. Consequence of these receptors regression is a reduced sensitivity to the body's chemical messengers.

Examples

Rebound comes, among others with long-term corticosteroid use after discontinuation of cortisone before, as when administering of antidotes which have a shorter plasma half-life than the poison (eg naloxone ). Furthermore, abrupt withdrawal of benzodiazepines can cause the phenomenon.