RIG-I

RIG-I ( retinoic acid inducible gene I) is one belonging to the helicases intracellular receptor of the innate immune system of mammals, which ( among other things, hepatitis C, influenza ) plays a central role in the recognition of several RNA viruses. The natural ligand of RIG-I was identified only in 2006. Be recognized single-and double ribonucleic acids with a triphosphate at the 5 ' end. This triphosphate RNA generated by viral polymerases and cellular RNA polymerase III.

RIG-I is activated by interferon - α, - β, - γ and bacterial lipopolysaccharide. Upon binding of the monomer to the triphosphate RNA takes place, and a conformational change of the receptor multimerized. So then MAVS/IPS1-Signalkaskade is triggered, IRF3, IRF7, and for distribution of antiviral cytokines such as interferon - β and CCR5 leads to the activation of NF-KB.

Protein isoform Human Genome Organisation Euteleostomi RNA-Virus Signal transduction
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