Kruse played in the youth at the Queensland Academy of Sport and the Australian Institute of Sport. As a professional, he was then working for Brisbane Roar and Melbourne Victory in Australia. In Germany since 2011 Kruse played as a striker for the German second division club Fortuna Dusseldorf. With this club he joined in 2012 in the Bundesliga and has played ( November 2012 ) all league games. His first Bundesliga goal he succeeded on November 10, 2012 ( 11th Round ) in the 1-1 draw at home against TSG 1899 Hoffenheim reduce the deficit to temporary 1-0 lead after 4 minutes. On November 23, 2012, he marked in the home stadium in Dusseldorf in injury time of the first half the opening goal (1-0 ) Fortuna Dusseldorf against HSV. On February 2, 2013, he helped his team by two goals to a 3-1 home win against VfB Stuttgart.
In April 2013, the Bundesliga club Bayer 04 Leverkusen announced that it would undertake the Australians for a transfer fee of 1.5 million Euros, even though his contract expires at the Fortuna valid until 2014. Reason for his departure is by its own account, that he would continue to "evolve as a footballer ." His first two goals for the " work self " Kruse scored on Matchday 6 on September 21, 2013 at 1:4 away win against 1 FSV Mainz 05
- Melbourne Victory's Young Player of the Season: 2009/10
- PFA Harry Kewell Medal ( U-23 Player of the Year ): 2010/11
- Nomination in the PFA Team of the Year: 2010/11
- PFA Footballer of the Year: 2012/13