Along with Jimmy Carl Black Estrada founded in 1964, the group "Soul Giants ". 1965 joined Frank Zappa to the group, which eventually became known, after several name changes as The Mothers of Invention. With this, he played a total of eight albums and worked beyond on a Zappa solo album. He was also involved in the albums produced by Zappa Permanent Damage the Groupie GTO band 's Trout Mask Replica and Captain Beefheart & His Magic Band.
In 1969 he left along with Lowell George, the Mothers to found Little Feat. Estrada played only on the first two albums and left the group in 1972. Briefly he became a member of Beefheart's Magic Band, which he knew from the earlier cooperation. Also, listen to Estrada's bass playing, among others, on Discover America by Van Dyke Parks, Mudlark by Leo Kottke, Ry Cooder and debut album. In 1975 and 1976 he was again with the Mothers on tour and played his album Zoot Allures Zappa with a. Between 1981 and 1984 he was involved in six other Zappa albums.
In 2003, Estrada's solo debut album Hamburger Midnight on the record label Inkanish Records, on which he collaborated once again with Jimmy Carl Black.
2012 joined the musicians to a fine imposed for continued child abuse 25 -year sentence.