Karam began his motorsport career in 2004 in karting, where he was active until 2009. In 2009, he debuted also in Formula racing. He reached the third place in the Skip Barber National Championship right away. In 2010 he received a contract with Andretti Autosport and was first used in the U.S. F2000 National Championship. He won nine out of twelve races and just stood in a race in which he did not finish the race, not on the podium. He scored the pole position in eleven races. Karam was a big margin champion and won the title premium in the amount of U.S. $ 350,000. 2011 Karam remained at Andretti Autosport and competed in the Star Mazda Series. He chose two oval racing for himself and was charged with four podium finishes fifth overall. 2012 Karam denied his second season in the Star Mazda Series for Andretti Autosport. He won three races and was ten times on the podium. In the overall standings, he improved to third place.
2013 Karam Andretti Autosport left and moved to Peterson Schmidt Motorsports in the Indy Lights. Karam won three races and was a total of nine times on the podium. Karam it, the champion to decide directly in his debut season for himself succeeded. With 460 to 449 points he won against his teammates Gabby Chaves.
- 2004-2009: Karting
- 2009: Skip Barber National Championship ( 3rd place)
- 2010: U.S. F2000 National Championship ( Champion)
- 2011: Star Mazda Series ( 5th place)
- 2012: Star Mazda Series ( 3rd place)
- 2013: Indy Lights (Master)