Septum transversum

The transverse septum is considered one of the forerunners of the diaphragm an embryonic structure that forms on the 23rd day of embryonic development below the heart system as a broad, horizontal thickening of the mesoderm and the chest cavity incomplete in defining of the abdominal cavity, as on either side of the foregut as Perikardioperitoneal or coelomic canals designated gaps remain.

From 24 days start derived from the endoderm, liver parenchymal cells in the septum vorzuwachsen transverse and this to penetrate so that it comes to a variety of interactions between the two types of tissue and ultimately the transverse stem from the connective tissue of the liver as well as their blood-forming cells and the Kupffer cells from the septum. In animal cells as has been demonstrated, for example, that these Gewebsinteraktionen between hepatic endoderm and mesenchyme differentiation of liver cells enabled, the culture of endoderm, in contrast, this is not allowed alone. Some cytokines and transcription factors have been identified between early as mediators of these processes.