Long is best known for the role of waitress Diane Chambers in the series Cheers, in which she was later replaced by Kirstie Alley. She played with Tom Hanks, the couple " Fielding " in the movie Money Pit, which is gift in Germany under the title still is too expensive known. Along with Bette Midler played Shelley Long in the crime comedy Nothing but trouble with the type. She had guest appearances in Sabrina - totally bewitched! as Wicked Witch (Season 2/Folge 16) and subsequently to the death of the series Boston Legal (Season 1/Folge 17).