Shiga-Toxin

  • UniProt: Q9FBI2

Shiga toxins are hot after the Japanese bacteriologist Kiyoshi Shiga named cytotoxic proteins, produced by Shigella dysenteriae, the causative agent of Shigellosen or dysentery, and closely related proteins of Escherichia coli ( enterohaemorrhagic Escherichia coli) produces ( Vero toxins).

The entire Shiga toxin has a molecular weight of about 70,000 daltons; The protein consists of two different subunits, which are linked by disulfide bridges. The B subunit (7.6 kDa) is five times available and provides for binding to the cell surface and that the A subunit ( about 30 kDa) is funneled into the cell interior, where this protein synthesis by cleavage of 28s rRNA the ribosomes inhibits. It has a pronounced neurotropism.

Shiga toxins are among the lectins. You are not responsible not enterotoxins and for diarrhea in dysentery, but - like the similar Vero toxins - for their hemolytic course.

Hydrolysis Shigellosis
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