SLC16A1

Monocarboxylate transporter 1 ( MCT1 ) ( gene: SLC16A1 ) is called the protein in the cell membrane of vertebrate cells, that catalyzes the diffusion of many monocarboxylic acids out of the cells. In particular the transport of lactic acid from muscle cells under anaerobic conditions and is essential in red blood cells, so as not to acidify the interior of the cell. Mutations in the SLC16A1 gene in humans can lead to transporter deficiency and ( rare, heritable ) inability to use muscles extreme; also are increased in the blood myoglobin and creatine kinase.

The catalyzed membrane transport equilibrium is:

It is a symport. As monocarboxylate act lactate, pyruvate, mevalonate, anions branched keto acids, β -hydroxybutyrate, γ -hydroxybutyrate, butyrate, acetoacetate, acetate and anions of valine and isoleucine.

Mandatory for the function of MCT1 necessary is the presence of Basigin, which is responsible as well as a chaperone for the localization of MCT1. Furthermore, the transporter activity stimulated by binding to the carbonate anhydrase 2.

Human Genome Organisation Major facilitator superfamily Euteleostomi Digital Object Identifier
560462
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