STAT protein

STAT proteins ( Signal Transducers and Activators abbreviation for of transcription ) are transcription factors that are present in all animals. They are the JAK -STAT signaling in the immune system, involved in cell growth and proliferation. In humans, seven STAT proteins are known. STAT mutations in genes responsible for hereditary diseases more:

Function in the JAK -STAT signaling pathway

The binding of extracellular cytokines activated intracellular Janus kinases which can phosphorylate tyrosine residues in the specific STAT proteins. The STAT monomers dimerize can it go through its SH2 domain. The dimer is then transported into the nucleus where it can initiate specific gene transcription.