After Accorsi had completed a science high school, he joined the drama school in Bologna. First experience in front of the camera he made in the 1992 film shot Fratelli e Sorelle. In 1993 he graduated from the school and began at the theater in Bologna as an actor at. The following year, he increased his popularity through television commercials for the Italian ice-cream producer Motta. The unexpectedly successful film Jack Frusciante è dal gruppo uscito finally opened in 1996 his career. His previous film credits earned him, among other things, the most important Italian film awards David di Donatello, the Nastro d' Argento, and the Best Actor Award at the film festival in Venice.
From the relationship to the French supermodel Laetitia Casta in 2006, entered a son out. Furthermore, Casta brought on 29 August 2009, a daughter named Athena to the world. Prior to 2001, Accorsi had been romantically involved with his Italian fellow actress Giovanna Mezzogiorno. Accorsi appeared in 1995 in the video clip to Una canzone d' amore the Italian band 883