Sterol regulatory element-binding protein

  • OMIM: 600481
  • UniProt: Q12772

SREBP stands for sterol regulatory element- binding protein. Sterol regulatory element -binding protein -1 ( SREBP1 ) and SREBP2 are structurally similar proteins that have a key role in the regulation of cholesterol metabolism.

Function

Influence after proteolytic activation by MBTPS1 with their acting as a transcription factor domain transcription of over 20 genes that have as a sterol regulatory element (SRE) sequence designated in its promoter region. SREBP can aufregulieren other genes within the cell and restore the balance within the cell due to increased absorption and increased synthesis of cholesterol at the same time a decrease in the cholesterol concentration. In medicine, different versions of SREBP play a role. SREBP1c gene variants (mutation in exon 18c), for example, a serious side effect ( high blood lipids and diabetes) predict in HIV therapies. The SREBP 1c is responsible for the synthesis of fatty acids and the 2 SREBP plays a critical role in cholesterol metabolism.

Protein isoform Human Genome Organisation Membrane-bound transcription factor peptidase, site 1 Promoter (genetics)
743082
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