STIM1
- OMIM: 605 921
- UniProt: Q13586
- OMIM: 610 841
- UniProt: Q9P246
The term stromal interaction molecule ( STIM abbreviated ) referred to in cell physiology, a protein that is involved in animals as a calcium sensor essential in the maintenance of calcium homeostasis or Calciumsignalgebung. In vertebrates, there are STIM1 and STIM2, which form as a homodimer or heterodimer sensory subunit of the CRAC channel. Mutations in the STIM1 gene are the cause of CRAC channel deficiency and consequent immune deficiency syndrome with T-cell inactivation ( IDTICED2 ).
There are two subtypes of STIM: STIM1 and STIM2. Both of which are membrane proteins, each with a transmembrane domain, which are mainly localized in the membrane of the endoplasmic reticulum, to a lesser extent also in the plasma membrane.