Suxamethonium chloride

  • Succinylcholine
  • 2,2 '- [ (1,4- Dioxobutan - 1,4- diyl) bis ( oxy) ] bis (N, N, N- trimethylethanaminium )
  • 306-40-1
  • 6101-15-1 ( dichloride )


Muscle relaxant

Template: Infobox chemical / molecular formula search available

Suxamethonium is a depolarising muscle relaxant, also known as succinylcholine or succinyldicholine (trade name Lysthenon ®) is known. It is used in medicine, to induce temporary paralysis. The substance acts as an agonist at the acetylcholine receptors of the motor end plate. Through a sustained depolarisation ( overdrive ) it finally comes to muscle paralysis. Muscle twitches ( fasciculations ) are triggered individually varying strength through the mechanism of action of the substance before the onset of paralysis for a short time. A triggered by the fasciculations breakdown of muscle cells can lead to a critical increase in serum potassium value and corresponding complications ( bradycardia, heart and circulatory standstill). In patients with diseases in which a disturbance of the stability of cell membranes is (about burn injury, polytrauma ) should not be used, therefore the substance. In patients who were immobile over a longer time ( for example, by being bedridden ), it may also come to the complications mentioned by an increased sensitivity of acetylcholine receptors.

  • Succinylcholine may be in rare cases trigger a life-threatening metabolic disease (malignant hyperthermia), and must therefore in patients with pre-existing disposition by appropriate pre-existing conditions (such as muscular dystrophy) are not used.
  • Furthermore, can rise through the fasciculations of intraocular pressure; so it should find no use even with Augapfelverletzungen.
  • In some of the patients treated with succinylcholine (known as myalgia ) may occur after surgery, muscle pain, muscle soreness which are not dissimilar in appearance. These symptoms can last up to a week.

The maximum onset of action of succinylcholine is fast ( about 1 minute) and the short duration of action (5-10 minutes). The substance is in clinical anesthesia as a muscle relaxant of choice for induction of anesthesia in non- fasting patients (Rapid Sequence Induction ), who have an increased risk of aspiration. In rare cases (for reducing the effect of the enzyme pseudocholinesterase ) the effect can be greatly extended, so that a longer Nachbeatmung may be necessary here.