Synephrine

• C01CA08
• S01GA06

Sympathomimetic Antihypotonikum

α1 -adrenoceptor agonist

184-185 ° C

8.9

Attention

270 mg · kg -1 ( LD50, mouse, i.v.)

Template: Infobox chemical / molecular formula search available

Synephrine is an alkaloid that is found in the bitter orange. As a phenylethylamine derivative is chemically and pharmacologically related to the ephedrine.

Synephrine is used as a metabolic stimulating and performance-enhancing use of funds. Bitter orange extract preparations are due to the Synephringehalts in weight loss help ( " fat burner " ), the effectiveness is controversial. In the U.S., synephrine is increasingly being used as a substitute for the prescription ephedrine there now.

Synephrine was patented in 1931 by Boehringer Ingelheim, is ( usually in the form of the tartrate ) used as a sympathomimetic. It is orally and intravenously for the treatment of low blood pressure ( " poor circulation ") and local ( eye drops) for decongesting the conjunctiva applicable, but has no specific therapeutic significance.

Risk assessment

For some products that are currently available on the market, are due to the dosage level sufficient suspicion that these products do not meet the requirements of Article 14 of Regulation ( EC) No 178 /2002 and are therefore classified as non- secure. This takes into account that the target group of the preparation are people who are already exposed due to physical exertion increased cardiovascular load, which is in the case of excess weight may increase even further.

Trade names

Sympatol ® (A, A. H. ), Dacryoboraline ® ( F, A. H. )