Tamsulosin

  • (R ) - (- ) -5 - {2 - [2 - (2- ethoxyphenoxy ) - ethylamino] -propyl} -2-methoxy - benzenesulfonamide

G04CA02

White to off- white powder ( tamsulosin hydrochloride · )

Alpha blockers

α1 -adrenoceptor antagonist

  • 408.51 g · mol -1 ( Tamsulosin)
  • 444.97 g.mol -1 ( · tamsulosin hydrochloride)

228-230 ° C ( · tamsulosin hydrochloride)

Sparingly soluble in water, slightly soluble in formic acid, sparingly soluble in ethanol ( tamsulosin hydrochloride · )

Hydrochloride

Attention

650 mg · kg -1 ( LD50, Rat, oral, hydrochloride)

Template: Infobox chemical / molecular formula search available

Tamsulosin is a drug from the class of alpha-adrenergic blocker used to treat symptoms of benign prostatic hyperplasia (BPH ) and is subject to medical prescription. Tamsulosin is a pharmaceutical application of tamsulosin hydrochloride.

Pharmacology

Areas of application and clinical effects

Tamsulosin is approved for the treatment of lower urinary tract symptoms in benign prostatic hyperplasia and apply for this indication as a drug of first choice. It shows, in comparison to other alpha blockers such as alfuzosin, doxazosin and a smaller effect of blood pressure (which can not always be excluded ).

A clinical study of kidney stone patients after ESWL treatment showed that patients treated with tamsulosin were better able to excrete stone debris.

Mechanism of Action

Tamsulosin is an antagonist at α1 -adrenoceptors. It is in contrast to other alpha-blockers, a comparatively high antagonistic selectivity for prostatic α1A/1L-Adrenozeptoren. This receptor selectivity on the one hand leads to a relaxation of the smooth muscle of the bladder neck, the urethra and the prostate, coupled with a relieved urine flow and, on the other hand, associated with a lower rate of side effects.

Side effects

Despite the prostate selectivity of alpha blockers can hypotension and orthostatic symptoms occur frequently ( 1-10 %), dizziness and occasionally (<1 %); often abnormal ejaculation (retrograde ejaculation) are observed. Rarely, it can lead to vascular syncope, a sudden loss of strength with loss of consciousness, also occasional to rare non-specific complaints of the gastrointestinal tract, such as nausea, diarrhea or constipation. In ophthalmology reported a correlation with the intraoperative "floppy - iris syndrome" with cataract surgery.

Interactions

Clinically significant interactions are not known.

Trade names

Aglandin (A), Alna (D, A), Flomax (USA), Omnic (D) Omix (CH), Pradif (CH), Prostacure (D), Prostadil (D), Prostalitan (D), Stichtulosin (A ) Tadin (D ), numerous generics (D, A, CH)

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Receptor antagonist Dangerous Substances Directive (67/548/EEC) Active ingredient Extracorporeal shock wave lithotripsy Smooth muscle tissue Drugs (journal)
620418
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