Teniposide

  • 4- Dimethylepipodophyllotoxin
  • Thenylidene -glucoside
  • 4 -dimethyl- 9-( 4,6-O- 2 - thenylidene - beta-D- glucopyranoside )
  • VM -26, VM26, NSC122819, NSC 12819

L01CB02

Cytostatic

Topoisomerase II inhibitor

242-246 ° C

10.3

Insoluble in water

Template: Infobox chemical / molecular formula search available

Teniposide (trade name: Vumon ®, Manufacturer: BristolMyersSquibb ) is a glycoside of podophyllotoxin. Because of its cell growth inhibitory effect, it is used as a cytostatic agent in the treatment of tumors. Teniposide made ​​semi- synthetically from the root of the evergreen American Maiapfels ( Podophyllum peltatum ).

Teniposide is a topoisomerase inhibitor. To inhibit topoisomerase II, and thus hinders the DNA replication in the cell during S- phase (and G2 - phase) of the cell cycle.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Type II topoisomerase Cancer Research (journal)
765139
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