Thiamphenicol

(1R, 2R ) -2,2 -dichloro -N-[ 1,3- dihydroxy- 1 - (4- methylsulfonylphenyl ) propan- 2-yl] -acetamide

QJ51BA02

Crystalline powder or crystals, fine, white to yellowish white

Antibiotic

From 164.3 to 166.3 ° C

Sparingly soluble in water, very slightly soluble in dimethylacetamide, slightly soluble in acetonitrile and dimethylformamide, soluble in methanol, slightly soluble in acetone and ethanol, slightly soluble in ethyl acetate

> 5000 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Thiamphenicol is an antibiotic. It is the methyl- sulphonyl analogue of chloramphenicol, and also has a similar spectrum of activity, however, is 2,5 - to 5 - times more potent. How chloramphenicol it is insoluble in water, but highly soluble in lipids. It is used in many countries in veterinary medicine, although it is approved in China, Italy and Turkey for humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anemia.

The chemical synthesis of Thiamphenocol described in the literature. A fluorinated analog is florfenicol.