Thrombomodulin

• OMIM: 188040
• UniProt: P07204
• MGI: 98736

Thrombomodulin ( THBD ) is a protein that functions in endothelial cells as a transmembrane receptor for thrombin and the capacity of thrombin to activate protein C, a thousand-fold. It thus plays a key role in the inhibition of blood clotting ( anticoagulation ). A lack of thrombomodulin by mutation at THBD gene may lead to thrombophilia and infarct inclination.

The ligand ensures thrombin in hemostasis as a clotting factor in blood clotting. However, the blood will coagulate only where the injury is. And if it is curdled, it will be released again until healing. Thrombomodulin binding site for thrombin in the blood vessel, which is unharmed. From here, the process is two-pronged further:

On the one hand, thrombin is inactivated by the binding but is still able to activate the protein C / protein S complex inactivated clotting factors FV and FVIII anyway. These factors may therefore not trigger further clotting.

By binding of thrombin thrombomodulin activates the other hand, TAFI ( thrombin activatable fibrinolysis inhibitor = " thrombin - activatable fibrinolysis inhibitor "). This ensures the inhibition of coagulation resolution. The graft has formed is not released again as long as the clot is still running.