Thyronamine

Thyronamines belong to a class of substances in the body of the thyroid hormones thyroxine ( T4) and triiodothyronine (T3 ) is synthesized. First, using T4 ( thyroxine). Deiodinierung through to T3 and then running the decarboxylation of the alanine residue to thyronamine That thyroxine as a prohormone, and thus as a precursor, acts is highly probable but at present still speculative.

Depending on the processing of Prohormones different molecules of Thyronamines can be formed. The designation is based on the number of iodine atoms, ranging from T0AM to T4AM.

Interestingly, not bind thyronamines despite their high structural relatedness with thyroid hormone to the thyroid hormone receptor ( a nuclear receptor ) but to a G -protein coupling receptor (ie a membrane receptor ). For T1AM has been shown that there is this to be a receptor of the TAAR family ( trace amine -associated receptor ).

In experiments with mice, it was shown that T1AM T0AM and are able to significantly reduce both heart rate and body temperature. This effect can be reversed by administration of isoproterenol.

Source

  • Scanlan et al.: 3- Iodothyronamine is an endogenous and rapid- acting derivative of thyroid hormone. in, Nat. Med 10 (6) :638-642 (2004). PMID 15146179
  • Stoffwechselintermediat
  • Substance Group
  • Phenol
  • Phenol
  • Phenylethylamine
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