Tiagabine

( -) - ( R) -1 - [4,4 -bis (3 -methyl- 2-thienyl) - but-3- enyl ] piperidine-3 -carboxylic acid

N03AG06

Antiepileptic

192 ° C ( · tiagabine hydrochloride)

Template: Infobox chemical / molecular formula search available

Tiagabine ( Gabitril ® trade name ) is an anticonvulsant drug that is used to treat epilepsy. Chemically, it is a derivative of Nipecotsäure.

Mechanism of Action

Tiagabine blocks the reuptake of the neurotransmitter gamma -aminobutyric acid ( GABA) in neurons. Thus the excitation inhibitory function is enhanced.

Areas of application

Tiagabine is used solely for adjunctive therapy in epilepsy with partial and secondarily generalized seizures.

Side effects

Depending on the dose occur dizziness, fatigue up to drowsiness, headaches, tremors, loss of balance, difficulty concentrating, mental slowing and nausea. Regardless dose allergic side effects occur with tiagabine hardly noticeable. With chronic use, however, it may cause a so-called nichtkonvulsiven status epilepticus in some cases, a series of small seizures with impairment of consciousness without motor manifestations.

Marketing

In Germany, the sales for November 2013 has been set. The provider Teva Pharmaceutical Industries called economic reasons.