Tolazoline

  • 2 - ( phenylmethyl ) -4,5 -dihydro -1H-imidazole (IUPAC)
  • 2-benzyl -2-imidazoline
  • 59-98-3
  • 59-97-2 (hydrochloride)
  • C04AB02
  • M02AX02

Sympatholytic

  • α2 - adrenoceptor antagonist
  • α1 -adrenoceptor antagonist (low)

66-69 ° C

Attention

350 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Tolazoline is a heterocyclic chemical compound that belongs to the group of the imidazole or imidazoline derivatives. The substance is used as a drug, is there to the α2 -adrenoceptor antagonists or to the sympatholytic. At the same time the effect of xylazine and other α2 - agonists is canceled. Tolazoline is used intravenously in the treatment of circulatory disorders ( vasodilator, such as the retina and in the Eisenmenger reaction) and in veterinary medicine.

Clinical information

Areas of application (indications )

For these indications, there is no authorization in Germany, Austria or Switzerland.

  • Vascular spasm of the central artery of the retina
  • Agents for treating cocaine overdose
CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Receptor antagonist Dangerous Substances Directive (67/548/EEC) Active ingredient Eisenmenger's syndrome
777842
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