Transthyretin

Transthyretin (TTR, thyroxine binding prealbumin, TBPA ) is a serum transport protein in vertebrates, formed in humans mainly in the choroid plexus and in the liver. It is involved in the transport of thyroid hormones. Mutations in the TTR gene can cause Transthyretinmangel and this amyloidosis type 1 or 7 and hyperthyroxinemia.

In the transthyretin serum electrophoresis migrates before the albumin fraction ( prealbumin ). It is involved in the binding of thyroxine and retinol and has a molar mass of about 55 kDa. In chronic active inflammatory conditions transthyretin is decreased. It is therefore referred to as anti- acute phase protein.

At the age transthyretin is involved in the formation of senile amyloidosis ( ATTR amyloidosis ). Genetically modified variants of transthyretin can lead to hereditary amyloidosis with an autosomal dominant mode of inheritance.

Human Genome Organisation Transportprotein Thyroxine-binding globulin
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