Tropomyosin

• OMIM: 191010
• UniProt: P09493

Tropomyosin is a fibrilliäres ( fibrous ) structural protein, which is involved in the contraction of the muscle cells. This myosin -like protein was discovered in 1946 by Bailey.

Tropomyosin is a rod-shaped molecule that is about 400 Å long, 20 Å wide and a molecular mass of 65-70 kDa. It consists of two subunits, α, β, wherein there are three isoforms of α ( α1, α3, α4 ). Skeletal muscle tropomyosin makes about 3 % of the total protein from muscle.

Changes in the genes that encode for the tropomyosin - subunits may have inherited diseases result in:

• α1: Hypertrophic cardiomyopathy ( CMH3 )
• Dilated cardiomyopathy ( CMD1Y )

• Nemaline myopathy -1 ( NEM1 )
• Papillary thyroid carcinoma (PACT )

• Nemaline myopathy -4 ( NEM4 )
• Arthrogryposis multiplex congenita (DA1 )

Binding of calcium ions to troponin C, the troponin / tropomyosin complex changes its conformation and thus reflects the Myosinbindungsstellen free, which allows a contraction.

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